West Nile Virus Treatment with High-Quality St. John’s Wort

West Nile Virus, although new to the US,

well documented. The Centers for Disease Control

identifies it as a flavivirus, a member of the

Togavirus family. It is closely related to yellow.

fever and dengue fever. This is important because

the Togavirus family are encapsulated viruses,

that is, they are covered with a (fatty) lipid

coating.

This is exciting, because it means that the virus is

accessible to treatment using St.

St. John’s Wort (SJW). Several studies have been conducted

in a variety of encapsulated viruses, including

herpes simplex virus types 1 and 2, parainfluenza

viruses, vaccinia virus, cytomegalovirus and various

retroviruses, including HIV1, 2, 3, 4, 8, 9, 10.

Non-encapsulated viruses or “naked” viruses were

also studied for comparative purposes10,13.

SJW was a potent antiviral agent in a variety of

encapsulated virus families, but did not show

activity against naked viruses.

Unlike a vaccine that is specific to each

organism, SJW is active against encapsulated

viruses by a variety of mechanisms, including

activation of light, interference with DNA

transcription, impairing the assembly of intact

viral and lipophilic (fat-loving) particles

nature of ring structures (quinone and

phenolic groups) 4, 6, 7, 9, 11, 12, 13, 14, 15.

These ring structures are critical to biology

SJW activity.

From these results, it is reasonable to use high

Pharmaceutical grade SJW to combat

West Nile virus, as they do not exist

pharmaceutical agents.

Quality is essential as the level of hypericin

and pseudohypericin are

key code. I can only recommend the SJW product

produced by Medi-Herb, which is a pharmaceutical product

home in Australia, adhering to the pharmaceutical industry

manufacturing standards. The product is

distributed by standard process through

alternative healthcare professionals, including

doctors of chiropractic, acupuncturists and

veterinarians. SJW is quite unstable and the

Active ingredients degrade on store shelves. Year

independent analysis of 3 products (all of which

were certified to contain 0.3% hypericin) were

proven to be highly variable, with a product of 25%

below the label claims. It is critically important

that the phytochemical integrity of the whole

the plant should be preserved for maximum effectiveness.

References:

1 Andersen DO, Weber ND, Wood SG et al. Antiviral

Res 1991; 16 (2): 185-196.

2Lopez-Bazzocchi I, Hudson JB, Towers GHN.

Photochem.Photopbiol. 1991; 54 (1): 95-98.

3 Moraleda G, Wu TT, Jilbert AR et al. Antiviral

Res 1993; 20: 235-247.

4Tang J, Colacino JM, Larsen SH et al. Antiviral

Res 1990; 13 (6): 313-325.

5Hudson JB, Harris L, Towers GHN. Antiviral Res

1993; 20 (2): 173-178.

6 Lenard J, Rabson A, Vanderoef R. Proc Natl Acad

Sci USA 1993; 90 (1): 158-162.

7 Degar S, Prince AM, Pascual D et al. AIDS Res Hum

Retrovirus 1992; 8 (11): 1929-1936.

8 Carpenter S, Kraus GA. Photochem Photobiol 1991;

53 (2): 169-174.

9 Lavie G, Valentine F, Levin B et al. Proc Natl

Acad Sci USA 1989; 86 (15): 5963-5967.

10 Meruelo D, Lavie G, Lavie D et al. Proc Natl

Acad Sci USA 1988; 85 (14): 5230-5234.

11 Kraus GA, Pratt D, Tossberg J et al. Biochemistry

Biophys Res Commun 1990; 172 (1): 149-153.

12 Takahashi I, Nakanishi S, Kobayashi E et al.

Biochem Biophys Res Commun 1989; 165 (3):

1207-1212.

13 De Witte P, Agostinis P, Van Lint J et al.

Biochem Pharmacol 1993; 46 (11): 1929-1936.

14Panossian AG, Gabrielian E, Manvelian V et al.

Phytomed 1996; 3 (1): 19-28.

15 Lavie G, Mazur Y, Lavie D et al. Transfusion

nineteen ninety five; 35 (5): 392-400.

16 Constantine GH, Karchesy J. Variations in

Hypericin concentrations in Hypericum perforatum

L. and commercial products. Pharmacist

Biology 1998; 36 (5): 365-367.

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